α‐Actinin‐1 promotes activity of the L‐type Ca(2+) channel Ca(v)1.2

The L‐type Ca(2+) channel Ca(V)1.2 governs gene expression, cardiac contraction, and neuronal activity. Binding of α‐actinin to the IQ motif of Ca(V)1.2 supports its surface localization and postsynaptic targeting in neurons. We report a bi‐functional mechanism that restricts Ca(V)1.2 activity to it...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Turner, Matthew, Anderson, David E, Bartels, Peter, Nieves‐Cintron, Madeline, Coleman, Andrea M, Henderson, Peter B, Man, Kwun Nok Mimi, Tseng, Pang‐Yen, Yarov‐Yarovoy, Vladimir, Bers, Donald M, Navedo, Manuel F, Horne, Mary C, Ames, James B, Hell, Johannes W
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049811/
https://ncbi.nlm.nih.gov/pubmed/31985069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102622
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