β-blockers augment L-type Ca(2+) channel activity by targeting spatially restricted β(2)AR signaling in neurons

G protein-coupled receptors (GPCRs) transduce pleiotropic intracellular signals in mammalian cells. Here, we report neuronal excitability of β-blockers carvedilol and alprenolol at clinically relevant nanomolar concentrations. Carvedilol and alprenolol activate β(2)AR, which promote G protein signal...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Shen, Ao, Chen, Dana, Kaur, Manpreet, Bartels, Peter, Xu, Bing, Shi, Qian, Martinez, Joseph M, Man, Kwun-nok Mimi, Nieves-Cintron, Madeline, Hell, Johannes W, Navedo, Manuel F, Yu, Xi-Yong, Xiang, Yang K
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813027/
https://ncbi.nlm.nih.gov/pubmed/31609201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49464
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados