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DNA binding modes influence Rap1 activity in the regulation of telomere length and MRX functions at DNA ends

The cellular response to DNA double-strand breaks (DSBs) is initiated by the Mre11–Rad50–Xrs2 (MRX) complex that has structural and catalytic functions. MRX association at DSBs is counteracted by Rif2, which is known to interact with Rap1 that binds telomeric DNA through two tandem Myb-like domains....

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Bonetti, Diego, Rinaldi, Carlo, Vertemara, Jacopo, Notaro, Marco, Pizzul, Paolo, Tisi, Renata, Zampella, Giuseppe, Longhese, Maria Pia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049697/
https://ncbi.nlm.nih.gov/pubmed/31879780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1203
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