Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin: the role of phosphodiesterase 3A

Prostacyclin (PGI(2)) controls platelet activation and thrombosis through a cyclic adenosine monophosphate (cAMP) signaling cascade. However, in patients with cardiovascular diseases this protective mechanism fails for reasons that are unclear. Using both pharmacological and genetic approaches we de...

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Veröffentlicht in:Haematologica
Hauptverfasser: Berger, Martin, Raslan, Zaher, Aburima, Ahmed, Magwenzi, Simbarashe, Wraith, Katie S., Spurgeon, Benjamin E.J., Hindle, Matthew S., Law, Robert, Febbraio, Maria, Naseem, Khalid M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2020
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049344/
https://ncbi.nlm.nih.gov/pubmed/31289200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.213348
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