Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade

Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in dyslipidemic disorders. Although oxLDL stimulates activatory signaling, it is unclear how these events drive accelerated thrombosis. Here, we describe a mechanism for oxLDL-mediated platelet hyperactivity that requi...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Magwenzi, Simbarashe, Woodward, Casey, Wraith, Katie S., Aburima, Ahmed, Raslan, Zaher, Jones, Huw, McNeil, Catriona, Wheatcroft, Stephen, Yuldasheva, Nadira, Febbriao, Maria, Kearney, Mark, Naseem, Khalid M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408294/
https://ncbi.nlm.nih.gov/pubmed/25710879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-574491
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