Oxidized low-density lipoproteins induce rapid platelet activation and shape change through tyrosine kinase and Rho kinase–signaling pathways

Oxidized low-density lipoproteins (oxLDL) generated in the hyperlipidemic state may contribute to unregulated platelet activation during thrombosis. Although the ability of oxLDL to activate platelets is established, the underlying signaling mechanisms remain obscure. We show that oxLDL stimulate pl...

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Bibliographische Detailangaben
Hauptverfasser: Wraith, Katie S., Magwenzi, Simbarashe, Aburima, Ahmed, Wen, Yichuan, Leake, David, Naseem, Khalid M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2013
Schlagworte:
Platelets and Thrombopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724193/
https://ncbi.nlm.nih.gov/pubmed/23699602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-491688
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