Dyslipidemia-associated atherogenic oxidized lipids induce platelet hyperactivity through phospholipase Cγ2-dependent reactive oxygen species generation

Oxidized low-density lipoprotein (oxLDL) and associated oxidized phosphocholine-headgroup phospholipids (oxPCs) activate blood platelets through ligation of the scavenger receptor CD36. Previously, we found that oxLDL stimulated phosphorylation of phospholipase Cγ2 (PLCγ2). However, the functional r...

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Dettagli Bibliografici
Pubblicato in:Platelets
Autori principali: Berger, Martin, Wraith, Katie, Woodward, Casey, Aburima, Ahmed, Raslan, Zaher, Hindle, Matthew S., Moellmann, Julia, Febbraio, Maria, Naseem, Khalid M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457275/
https://ncbi.nlm.nih.gov/pubmed/29733744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/09537104.2018.1466386
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