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Macropinocytosis confers resistance to therapies targeting cancer anabolism
Macropinocytic cancer cells scavenge amino acids from extracellular proteins. Here, we show that consuming necrotic cell debris via macropinocytosis (necrocytosis) offers additional anabolic benefits. A click chemistry-based flux assay reveals that necrocytosis provides not only amino acids, but sug...
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| Udgivet i: | Nat Commun |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7048872/ https://ncbi.nlm.nih.gov/pubmed/32111826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14928-3 |
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