An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing

The ability of HIV-1 to evolve resistance to combined antiretroviral therapies (cARTs) has stimulated research into alternative means of controlling this infection. We assayed >60 modulators of RNA alternative splicing (AS) to identify new inhibitors of HIV-1 RNA processing—a segment of the viral...

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Publicado en:PLoS Pathog
Autores principales: Wong, Raymond W., Balachandran, Ahalya, Cheung, Peter K., Cheng, Ran, Pan, Qun, Stoilov, Peter, Harrigan, P. Richard, Blencowe, Benjamin J., Branch, Donald R., Cochrane, Alan
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048317/
https://ncbi.nlm.nih.gov/pubmed/32069328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008307
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