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Plasma membrane v-ATPase controls oncogenic Ras-induced macropinocytosis
Oncogenic activation of Ras is associated with the acquisition of a unique set of metabolic dependencies that contribute to tumor cell fitness. Mutant Ras cells are endowed with the capability to internalize and degrade extracellular protein via a fluid–phase uptake mechanism termed macropinocytosis...
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| Publicado en: | Nature |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7048194/ https://ncbi.nlm.nih.gov/pubmed/31827278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1831-x |
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