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Cryo-Electron Microscopy Structure of the αIIbβ3–Abciximab Complex
OBJECTIVE: The αIIbβ3 antagonist anti-platelet drug abciximab is the chimeric antigen-binding fragment (Fab) comprising the variable regions of murine mAb 7E3 and the constant domains of human IgG1 and light chain κ. Previous mutagenesis studies suggested that abciximab binds to the β3 C177-C184 spe...
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| Udgivet i: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7047619/ https://ncbi.nlm.nih.gov/pubmed/31969014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.313671 |
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