Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin αIIbβ3 for ligand binding

The murine monoclonal antibody (mAb) PT25-2 induces αIIbβ3 to bind ligand and initiate platelet aggregation. The underlying mechanism is unclear, because previous mutagenesis studies suggested that PT25-2 binds to the αIIb β propeller, a site distant from the Arg-Gly-Asp–binding pocket. To elucidate...

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Vydáno v:Blood Adv
Hlavní autoři: Nešić, Dragana, Bush, Martin, Spasic, Aleksandar, Li, Jihong, Kamata, Tetsuji, Handa, Makoto, Filizola, Marta, Walz, Thomas, Coller, Barry S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2021
Témata:
Platelets and Thrombopoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045492/
https://ncbi.nlm.nih.gov/pubmed/33760023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020004166
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