αIIbβ3 binding to a fibrinogen fragment lacking the γ-chain dodecapeptide is activation dependent and EDTA inducible

Platelet integrin receptor αIIbβ3 supports platelet aggregation by binding fibrinogen. The interaction between the fibrinogen C-terminal γ-chain peptide composed of residues γ-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on αIIbβ3 is required for fibrinogen-mediated platelet aggregati...

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Udgivet i:Blood Adv
Main Authors: Zafar, Hina, Shang, Yi, Li, Jihong, David, George A., Fernandez, Joseph P., Molina, Henrik, Filizola, Marta, Coller, Barry S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2017
Fag:
Platelets and Thrombopoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738983/
https://ncbi.nlm.nih.gov/pubmed/29296957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017004689
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