Aromatic-Amine Pendants Produce Highly Potent and Efficacious Mixed Efficacy Mu-Opioid Receptor (MOR)/Delta-Opioid Receptor (DOR) Peptidomimetics with Enhanced Metabolic Stability.

We previously reported a novel SAR campaign that converted a metabolically unstable series of μ-opioid receptor (MOR) agonist/ δ-opioid receptor (DOR) antagonist bicyclic core peptidomimetics with promising analgesic activity and reduced abuse liabilities into a more stable series of benzylic core a...

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Publicat a:J Med Chem
Autors principals: Henry, Sean, Anand, Jessica P., Twarozynski, Jack J., Brinkel, Ashley C., Pogozheva, Irina D., Sears, Bryan F., Jutkiewicz, Emily M., Traynor, John R., Mosberg, Henry I.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047604/
https://ncbi.nlm.nih.gov/pubmed/31986033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01818
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