IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease

Coeliac disease (CeD) is a complex, polygenic inflammatory enteropathy caused by exposure to dietary gluten that selectively occurs in a subset of genetically susceptible HLA-DQ8 and HLA-DQ2 individuals(1,2). The need to develop non-dietary treatments is now widely recognized(3), but it is hampered...

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Pubblicato in:Nature
Autori principali: Abadie, Valérie, Kim, Sangman M., Lejeune, Thomas, Palanski, Brad A., Ernest, Jordan D., Tastet, Olivier, Voisine, Jordan, Discepolo, Valentina, Marietta, Eric V., Hawash, Mohamed B. F., Ciszewski, Cezary, Bouziat, Romain, Panigrahi, Kaushik, Horwath, Irina, Zurenski, Matthew A., Lawrence, Ian, Dumaine, Anne, Yotova, Vania, Grenier, Jean-Christophe, Murray, Joseph A., Khosla, Chaitan, Barreiro, Luis B., Jabri, Bana
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047598/
https://ncbi.nlm.nih.gov/pubmed/32051586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2003-8
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