IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease

Coeliac disease (CeD) is a complex, polygenic inflammatory enteropathy caused by exposure to dietary gluten that selectively occurs in a subset of genetically susceptible HLA-DQ8 and HLA-DQ2 individuals(1,2). The need to develop non-dietary treatments is now widely recognized(3), but it is hampered...

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Vydáno v:Nature
Hlavní autoři: Abadie, Valérie, Kim, Sangman M., Lejeune, Thomas, Palanski, Brad A., Ernest, Jordan D., Tastet, Olivier, Voisine, Jordan, Discepolo, Valentina, Marietta, Eric V., Hawash, Mohamed B. F., Ciszewski, Cezary, Bouziat, Romain, Panigrahi, Kaushik, Horwath, Irina, Zurenski, Matthew A., Lawrence, Ian, Dumaine, Anne, Yotova, Vania, Grenier, Jean-Christophe, Murray, Joseph A., Khosla, Chaitan, Barreiro, Luis B., Jabri, Bana
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047598/
https://ncbi.nlm.nih.gov/pubmed/32051586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2003-8
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