Hematopoietic cell-expressed endothelial nitric oxide protects the liver from insulin resistance

OBJECTIVE: Mice genetically deficient in endothelial nitric oxide synthase (Nos3(−/−)) have fasting hyperinsulinemia and hepatic insulin resistance, indicating the importance of Nos3 in maintaining metabolic homeostasis. Although the current paradigm holds that these metabolic effects are derived sp...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Dick, Brian P., McMahan, Ryan, Knowles, Taft, Becker, Lev, Gharib, Sina A., Vaisar, Tomas, Wietecha, Tomasz, O’Brien, Kevin D., Bornfeldt, Karin E., Chait, Alan, Kim, Francis
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047596/
https://ncbi.nlm.nih.gov/pubmed/31996027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.313648
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