Sexually dimorphic relationships among serum amyloid A3, inflammation, and cholesterol metabolism modulate atherosclerosis in mice

OBJECTIVE: Expression of the extrahepatic acute-phase protein serum amyloid A3 (Saa3) increases in response to acute and chronic inflammatory stimuli and is elevated in adipose tissue and macrophages in obese mice. A recent report suggested that Saa3 is pro-atherogenic in male ApoE(−/−) mice. Due to...

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Published in:Arterioscler Thromb Vasc Biol
Main Authors: Chait, A, Wang, S, Goodspeed, L, Gomes, D, Turk, KE, Wietecha, T, Tang, J, Storey, C, O’Brien, KD, Rubinow, KB, Tang, C, Vaisar, T, Gharib, SA, Lusis, AJ, den Hartigh, LJ
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159856/
https://ncbi.nlm.nih.gov/pubmed/33761762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.121.316066
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