In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand

The cardinal role of microtubules in cell mitosis makes them interesting drug targets for many pharmacological treatments, including those against cancer. Moreover, different expression patterns between cell types for several tubulin isotypes represent a great opportunity to improve the selectivity...

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Bibliographic Details
Published in:Front Chem
Main Authors: Pallante, Lorenzo, Rocca, Antonio, Klejborowska, Greta, Huczynski, Adam, Grasso, Gianvito, Tuszynski, Jack A., Deriu, Marco A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047339/
https://ncbi.nlm.nih.gov/pubmed/32154219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00108
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