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In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand

The cardinal role of microtubules in cell mitosis makes them interesting drug targets for many pharmacological treatments, including those against cancer. Moreover, different expression patterns between cell types for several tubulin isotypes represent a great opportunity to improve the selectivity...

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Bibliografski detalji
Izdano u:Front Chem
Glavni autori: Pallante, Lorenzo, Rocca, Antonio, Klejborowska, Greta, Huczynski, Adam, Grasso, Gianvito, Tuszynski, Jack A., Deriu, Marco A.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047339/
https://ncbi.nlm.nih.gov/pubmed/32154219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00108
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