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Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents

Specific modifications of colchicine followed by synthesis of its analogues have been tested in vitro with the objective of lowering colchicine toxicity. Our previous studies have clearly shown the anticancer potential of double-modified colchicine derivatives in C-7 and C-10 positions. Here, a seri...

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Publicat a:Cells
Autors principals: Majcher, Urszula, Klejborowska, Greta, Kaik, Magdalena, Maj, Ewa, Wietrzyk, Joanna, Moshari, Mahshad, Preto, Jordane, Tuszynski, Jack A., Huczyński, Adam
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262455/
https://ncbi.nlm.nih.gov/pubmed/30463236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells7110216
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