Loading...
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model
TREM2 is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus PS2APP mice lacking Trem2 (PS2APP;Trem2(ko)) at ages ranging from 4 to 22 months. Microgliosis was impaired in PS2APP;Tr...
Na minha lista:
| Udgivet i: | J Neurosci |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Society for Neuroscience
2020
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7046459/ https://ncbi.nlm.nih.gov/pubmed/31980586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1871-19.2019 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|