Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS

RIP1 kinase is proposed to play a critical role in driving necroptosis and inflammation in neurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS). Preclinical studies indicated that while pharmacological inhibition of RIP1 kinase can ameliorate axonal pathology and delay disease...

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Publicado en:Cell Death Differ
Main Authors: Dominguez, Sara, Varfolomeev, Eugene, Brendza, Robert, Stark, Kim, Tea, Joy, Imperio, Jose, Ngu, Hai, Earr, Timothy, Foreman, Oded, Webster, Joshua D., Easton, Amy, Vucic, Domagoj, Bingol, Baris
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7937687/
https://ncbi.nlm.nih.gov/pubmed/32994544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00625-7
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