Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS

RIP1 kinase is proposed to play a critical role in driving necroptosis and inflammation in neurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS). Preclinical studies indicated that while pharmacological inhibition of RIP1 kinase can ameliorate axonal pathology and delay disease...

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Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Differ
Egile Nagusiak: Dominguez, Sara, Varfolomeev, Eugene, Brendza, Robert, Stark, Kim, Tea, Joy, Imperio, Jose, Ngu, Hai, Earr, Timothy, Foreman, Oded, Webster, Joshua D., Easton, Amy, Vucic, Domagoj, Bingol, Baris
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7937687/
https://ncbi.nlm.nih.gov/pubmed/32994544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00625-7
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