Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury

RIP1 kinase-mediated inflammatory and cell death pathways have been implicated in the pathology of acute and chronic disorders of the nervous system. Here, we describe a novel animal model of RIP1 kinase deficiency, generated by knock-in of the kinase-inactivating RIP1(D138N) mutation in rats. Homoz...

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Udgivet i:Cell Death Dis
Main Authors: Stark, Kimberly, Goncharov, Tatiana, Varfolomeev, Eugene, Xie, Luke, Ngu, Hai, Peng, Ivan, Anderson, Keith R., Verschueren, Erik, Choi, Meena, Kirkpatrick, Donald S., Easton, Amy, Webster, Joshua D., McKenzie, Brent S., Vucic, Domagoj, Bingol, Baris
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026634/
https://ncbi.nlm.nih.gov/pubmed/33828080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03651-6
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