Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

TREM2 is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus PS2APP mice lacking Trem2 (PS2APP;Trem2(ko)) at ages ranging from 4 to 22 months. Microgliosis was impaired in PS2APP;Tr...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Meilandt, William J., Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J., Stark, Kimberly L., Chan, Pamela, Kwong, Mandy, Modrusan, Zora, Friedman, Brad A., Elstrott, Justin, Foreman, Oded, Easton, Amy, Sheng, Morgan, Hansen, David V.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046459/
https://ncbi.nlm.nih.gov/pubmed/31980586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1871-19.2019
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