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Protein−Nucleic Acid Conjugation with Sterol Linkers Using Hedgehog Autoprocessing

Hedgehog (Hh) precursor proteins contain an autoprocessing domain called HhC whose native function is protein cleavage and C-terminal glycine sterylation. The transformation catalyzed by HhC occurs in cis from a precursor protein and exhibits wide tolerance toward both sterol and protein substrates....

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Foilsithe in:Bioconjug Chem
Main Authors: Zhang, Xiaoyu, Xu, Zihan, Moumin, Dina S., Ciulla, Daniel A., Owen, Timothy S., Mancusi, Rebecca A., Giner, José-Luis, Wang, Chunyu, Callahan, Brian P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7045895/
https://ncbi.nlm.nih.gov/pubmed/31600061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.9b00550
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