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Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis
Hedgehog proteins, a family of vital cell signaling factors, are expressed in precursor form, which requires specialized autoprocessing, called cholesterolysis, for full biological activity. Cholesterolysis occurs in cis through the action of the precursor’s C-terminal enzymatic domain, HhC. In this...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7031038/ https://ncbi.nlm.nih.gov/pubmed/32013401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00013 |
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