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A Single Aspartate Coordinates Two Catalytic Steps in Hedgehog Autoprocessing
Hedgehog (Hh) signaling is driven by the cholesterol-modified Hh ligand, generated by autoprocessing of Hh precursor protein. Two steps in Hh autoprocessing, N–S acyl shift and transesterification, must be coupled for efficient Hh cholesteroylation and downstream signal transduction. In the present...
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Publicado no: | J Am Chem Soc |
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Main Authors: | , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5589136/ https://ncbi.nlm.nih.gov/pubmed/27529645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b06928 |
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