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A Single Aspartate Coordinates Two Catalytic Steps in Hedgehog Autoprocessing

Hedgehog (Hh) signaling is driven by the cholesterol-modified Hh ligand, generated by autoprocessing of Hh precursor protein. Two steps in Hh autoprocessing, N–S acyl shift and transesterification, must be coupled for efficient Hh cholesteroylation and downstream signal transduction. In the present...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Xie, Jian, Owen, Timothy, Xia, Ke, Callahan, Brian, Wang, Chunyu
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589136/
https://ncbi.nlm.nih.gov/pubmed/27529645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b06928
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