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Active Site Targeting of Hedgehog Precursor Protein with Phenylarsine Oxide
Hedgehog proteins, signaling molecules implicated in human embryo development and cancer, can be inhibited at the stage of autoprocessing by the trivalent arsenical phenyl arsine oxide (PhAs(III)). The interaction (apparent K(i), 4×10(−7)M) is characterized by an optical binding assay and by NMR spe...
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| Publicado no: | Chembiochem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4430098/ https://ncbi.nlm.nih.gov/pubmed/25418613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402421 |
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