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Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation
Sonic hedgehog (Shh) is a signaling molecule that is important for defining patterning in the developing vertebrate central nervous system. After translation, Shh autoproteolyzes and covalently attaches cholesterol to the newly formed carboxyl terminus, a modification crucial for normal Shh signalin...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2000
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC16541/ https://ncbi.nlm.nih.gov/pubmed/10860995 |
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