Development and validation of UPLC-MS/MS method for studying the pharmacokinetic interaction of dasabuvir and tamoxifen, 4-hydroxytamoxifen in Wistar rats

Hepatitis C virus (HCV) is the main cause of chronic hepatitis and probably liver cirrhosis. Dasabuvir (DSV) is a direct-acting antiviral agent with efficiency in managing HCV. The anti-viral activity of the anti-estrogen drug tamoxifen (TAM) suggested the synergistic effect of DSV and TAM for block...

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Vydáno v:Sci Rep
Hlavní autoři: Almomen, Aliyah, Maher, Hadir M., Alzoman, Nourah Z., Shehata, Shereen M., Al-taweel, Shorog M., Alanazi, Ashwaq A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7044166/
https://ncbi.nlm.nih.gov/pubmed/32103133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60613-2
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