Flavoured water consumption alters pharmacokinetic parameters and increases exposure of erlotinib and gefitinib in a preclinical study using Wistar rats

BACKGROUND: Erlotinib (ERL) and Gefitinib (GEF) are considered first line therapy for the management of non-small cell lung carcinoma (NSCLC). Like other tyrosine kinase inhibitors (TKIs), ERL and GEF are mainly metabolized by the cytochrome P450 (CYP450) CYP3A4 isoform and are substrates for transp...

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Detalles Bibliográficos
Publicado en:PeerJ
Main Authors: Almomen, Aliyah, Maher, Hadir M., Alzoman, Nourah Z., Shehata, Shereen M., Alsubaie, Amal
Formato: Artigo
Idioma:Inglês
Publicado: PeerJ Inc. 2020
Assuntos:
Toxicology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7518156/
https://ncbi.nlm.nih.gov/pubmed/33024629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.9881
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