Flavoured water consumption alters pharmacokinetic parameters and increases exposure of erlotinib and gefitinib in a preclinical study using Wistar rats

BACKGROUND: Erlotinib (ERL) and Gefitinib (GEF) are considered first line therapy for the management of non-small cell lung carcinoma (NSCLC). Like other tyrosine kinase inhibitors (TKIs), ERL and GEF are mainly metabolized by the cytochrome P450 (CYP450) CYP3A4 isoform and are substrates for transp...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:PeerJ
Autori principali: Almomen, Aliyah, Maher, Hadir M., Alzoman, Nourah Z., Shehata, Shereen M., Alsubaie, Amal
Natura: Artigo
Lingua:Inglês
Pubblicazione: PeerJ Inc. 2020
Soggetti:
Toxicology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7518156/
https://ncbi.nlm.nih.gov/pubmed/33024629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.9881
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi