HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells

HIV-1 infection is associated with heightened inflammation and excess risk of cardiovascular disease, cancer, and other complications. These pathologies persist despite antiretroviral therapy (ART). In two independent cohorts, we found that innate lymphoid cells (ILCs) were depleted in the blood and...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Wang, Yetao, Lifshitz, Lawrence, Gellatly, Kyle, Vinton, Carol L., Busman-Sahay, Kathleen, McCauley, Sean, Vangala, Pranitha, Kim, Kyusik, Derr, Alan, Jaiswal, Smita, Kucukural, Alper, McDonel, Patrick, Hunt, Peter W., Greenough, Thomas, Houghton, JeanMarie, Somsouk, Ma, Estes, Jacob D., Brenchley, Jason M., Garber, Manuel, Deeks, Steven G., Luban, Jeremy
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7044076/
https://ncbi.nlm.nih.gov/pubmed/32066947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0593-9
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