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NRF2 negatively regulates primary ciliogenesis and hedgehog signaling
Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear factor-erythroid 2-like 2 (NRF2) protects cells from oxidative, proteotoxic, and metabolic stress in normal cells, hyperactivation of NRF2 is oncoge...
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| Publicado no: | PLoS Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7043785/ https://ncbi.nlm.nih.gov/pubmed/32053600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000620 |
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