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NRF2 negatively regulates primary ciliogenesis and hedgehog signaling

Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear factor-erythroid 2-like 2 (NRF2) protects cells from oxidative, proteotoxic, and metabolic stress in normal cells, hyperactivation of NRF2 is oncoge...

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Bibliografiska uppgifter
I publikationen:PLoS Biol
Huvudupphovsmän: Liu, Pengfei, Dodson, Matthew, Fang, Deyu, Chapman, Eli, Zhang, Donna D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043785/
https://ncbi.nlm.nih.gov/pubmed/32053600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000620
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