Investigation of the Structural Requirements for N-Methyl-D-Aspartate Receptor Positive and Negative Allosteric Modulators Based on 2-Naphthoic Acid

The N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel activated by L-glutamate and glycine, plays a major role in the synaptic plasticity underlying learning and memory. NMDARs are involved in neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease and NMDAR hypofunct...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Eur J Med Chem
Päätekijät: Irvine, Mark W., Fang, Guangyu, Sapkota, Kiran, Burnell, Erica S., Volianskis, Arturas, Costa, Blaise M., Culley, Georgia, Collingridge, Graham L., Monaghan, Daniel T., Jane, David E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043280/
https://ncbi.nlm.nih.gov/pubmed/30622023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.12.054
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