High-risk LCH in infants is serially transplantable in a xenograft model but responds durably to targeted therapy

Langerhans cell histiocytosis (LCH) is a rare hematologic neoplasm characterized by a clonal proliferation of Langerhans-like cells. Genomic profiling has identified recurrent somatic activating mutations in the mitogen-activated protein kinase pathway, which are targetable by small-molecule inhibit...

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Publicado en:Blood Adv
Autores principales: Lee, Lynn H., Krupski, Christa, Clark, Jason, Wunderlich, Mark, Lorsbach, Robert B., Grimley, Michael S., Burwinkel, Matthew, Nelson, Adam, Kumar, Ashish R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2020
Materias:
Myeloid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042980/
https://ncbi.nlm.nih.gov/pubmed/32092141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019032367
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