HSD3B1 Genotype and Clinical Outcomes in Metastatic Castration-Sensitive Prostate Cancer

IMPORTANCE: The adrenal-restrictive HSD3B1(1245A) allele limits extragonadal dihydrotestosterone synthesis, whereas the adrenal-permissive HSD3B1(1245C) allele augments extragonadal dihydrotestosterone synthesis. Retrospective studies have suggested an association between the adrenal-permissive alle...

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Bibliografiske detaljer
Udgivet i:JAMA Oncol
Main Authors: Hearn, Jason W. D., Sweeney, Christopher J., Almassi, Nima, Reichard, Chad A., Reddy, Chandana A., Li, Hong, Hobbs, Brian, Jarrard, David F., Chen, Yu-Hui, Dreicer, Robert, Garcia, Jorge A., Carducci, Michael A., DiPaola, Robert S., Sharifi, Nima
Format: Artigo
Sprog:Inglês
Udgivet: American Medical Association 2020
Fag:
Original Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042830/
https://ncbi.nlm.nih.gov/pubmed/32053149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2019.6496
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