Association of HSD3B1 Genotype With Response to Androgen-Deprivation Therapy for Biochemical Recurrence After Radiotherapy for Localized Prostate Cancer

IMPORTANCE: The variant HSD3B1 (1245C) allele enhances dihydrotestosterone synthesis and predicts resistance to androgen-deprivation therapy (ADT) for biochemically recurrent prostate cancer after prostatectomy and for metastatic disease. Whether this is true after radiotherapy is unknown. OBJECTIVE...

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Pubblicato in:JAMA Oncol
Autori principali: Hearn, Jason W. D., Xie, Wanling, Nakabayashi, Mari, Almassi, Nima, Reichard, Chad A., Pomerantz, Mark, Kantoff, Philip W., Sharifi, Nima
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Medical Association 2017
Soggetti:
Brief Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5933377/
https://ncbi.nlm.nih.gov/pubmed/29049492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2017.3164
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