A genetic variation of SOD2 does not determine duration of response to androgen deprivation therapy for prostate cancer

BACKGROUND: Silencing SOD2 expression up-regulates AR signaling and expression of SOD2 is down-regulated in CRPC, compared with untreated tumors. The decreased SOD2 activity could lead to AR gain-of-function and the development of castration-resistance. METHOD: We genotyped SOD2-rs4880 in a cohort o...

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Dettagli Bibliografici
Pubblicato in:Prostate
Autori principali: Xie, Wanling, Drouin, Sarah, Nakabayashi, Mari, Pomerantz, Mark, Lee, Gwo-Shu Mary, Kantoff, Philip W., Sharifi, Nima
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5637518/
https://ncbi.nlm.nih.gov/pubmed/27325180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.23220
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