HSD3B1 and Response to a Nonsteroidal CYP17A1 Inhibitor in Castration-Resistant Prostate Cancer

IMPORTANCE: The HSD3B1 (1245C) germline variant encodes for a gain-of-function missense in 3β-hydroxysteroid dehydrogenase isoenzyme 1 (3βHSD1) that results in increased dihydrotestosterone synthesis from extragonadal precursors and is predictive of more rapid progression to castration-resistant pro...

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Detalhes bibliográficos
Publicado no:JAMA Oncol
Main Authors: Almassi, Nima, Reichard, Chad, Li, Jianbo, Russell, Carly, Perry, Jaselle, Ryan, Charles J., Friedlander, Terence, Sharifi, Nima
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2017
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5933361/
https://ncbi.nlm.nih.gov/pubmed/29049452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2017.3159
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