HSD3B1 and Resistance to Androgen Deprivation Therapy in Prostate Cancer: A Multi-Cohort Study

BACKGROUND: HSD3B1(1245A>C) has been mechanistically linked to castration-resistant prostate cancer by encoding an altered enzyme that augments dihydrotestosterone synthesis. We hypothesized that men inheriting the HSD3B1(1245C) allele would exhibit resistance to androgen deprivation therapy (ADT...

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Pubblicato in:Lancet Oncol
Autori principali: Hearn, Jason W.D., AbuAli, Ghada, Reichard, Chad A, Reddy, Chandana A, Magi-Galluzzi, Cristina, Chang, Kai-Hsiung, Carlson, Rachel, Rangel, Laureano, Reagan, Kevin, Davis, Brian J, Karnes, R. Jeffrey, Kohli, Manish, Tindall, Donald, Klein, Eric A, Sharifi, Nima
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135009/
https://ncbi.nlm.nih.gov/pubmed/27575027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(16)30227-3
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