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β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery

Acid-sensing ion channels (ASICs) are neuronal sodium-selective channels activated by reductions in extracellular pH. Structures of the three presumptive functional states, high-pH resting, low-pH desensitized, and toxin-stabilized open, have all been solved for chicken ASIC1. These structures, alon...

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發表在:eLife
Main Authors: Rook, Matthew L, Williamson, Abby, Lueck, John D, Musgaard, Maria, Maclean, David M
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2020
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041949/
https://ncbi.nlm.nih.gov/pubmed/32031522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51111
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