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β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery
Acid-sensing ion channels (ASICs) are neuronal sodium-selective channels activated by reductions in extracellular pH. Structures of the three presumptive functional states, high-pH resting, low-pH desensitized, and toxin-stabilized open, have all been solved for chicken ASIC1. These structures, alon...
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| Publié dans: | eLife |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
eLife Sciences Publications, Ltd
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7041949/ https://ncbi.nlm.nih.gov/pubmed/32031522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51111 |
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