Adjunctive sertraline in HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial

BACKGROUND: Identifying new antifungals for cryptococcal meningitis remains a priority given the inadequacy of current therapy. Sertraline has previously demonstrated in vitro and in vivo activity against Cryptococcus. We evaluated the efficacy of adjunctive sertraline for cryptococcal meningitis in...

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Pubblicato in:Lancet Infect Dis
Autori principali: Rhein, Joshua, Huppler Hullsiek, Kathy, Tugume, Lillian, Nuwagira, Edwin, Mpoza, Edward, Evans, Emily E., Kiggundu, Reuben, Pastick, Katelyn A., Ssebambulidde, Kenneth, Akampurira, Andrew, Williams, Darlisha A., Bangdiwala, Ananta S., Abassi, Mahsa, Musubire, Abdu K., Nicol, Melanie R., Muzoora, Conrad, Meya, David B., Boulware, David R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041360/
https://ncbi.nlm.nih.gov/pubmed/31345462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(19)30127-6
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