Cerebrospinal Fluid Early Fungicidal Activity as a Surrogate Endpoint for Cryptococcal Meningitis Survival in Clinical Trials

BACKGROUND: In cryptococcal meningitis phase 2 clinical trials, early fungicidal activity (EFA) of Cryptococcus clearance from cerebrospinal fluid (CSF) is used as a surrogate endpoint for all-cause mortality. The Food and Drug Administration allows for using surrogate endpoints for accelerated regu...

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Bibliografske podrobnosti
izdano v:Clin Infect Dis
Main Authors: Pullen, Matthew F, Hullsiek, Katherine Huppler, Rhein, Joshua, Musubire, Abdu K, Tugume, Lillian, Nuwagira, Edwin, Abassi, Mahsa, Ssebambulidde, Kenneth, Mpoza, Edward, Kiggundu, Ruben, Akampurira, Andrew, Nabeta, Henry W, Schutz, Charlotte, Evans, Emily E, Rajasingham, Radha, Skipper, Caleb P, Pastick, Katelyn A, Williams, Darlisha A, Morawski, Bozena M, Bangdiwala, Ananta S, Meintjes, Graeme, Muzoora, Conrad, Meya, David B, Boulware, David R
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Online Only Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755087/
https://ncbi.nlm.nih.gov/pubmed/31912875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciaa016
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