Cerebrospinal Fluid Early Fungicidal Activity as a Surrogate Endpoint for Cryptococcal Meningitis Survival in Clinical Trials

BACKGROUND: In cryptococcal meningitis phase 2 clinical trials, early fungicidal activity (EFA) of Cryptococcus clearance from cerebrospinal fluid (CSF) is used as a surrogate endpoint for all-cause mortality. The Food and Drug Administration allows for using surrogate endpoints for accelerated regu...

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Detaylı Bibliyografya
Yayımlandı:Clin Infect Dis
Asıl Yazarlar: Pullen, Matthew F, Hullsiek, Katherine Huppler, Rhein, Joshua, Musubire, Abdu K, Tugume, Lillian, Nuwagira, Edwin, Abassi, Mahsa, Ssebambulidde, Kenneth, Mpoza, Edward, Kiggundu, Ruben, Akampurira, Andrew, Nabeta, Henry W, Schutz, Charlotte, Evans, Emily E, Rajasingham, Radha, Skipper, Caleb P, Pastick, Katelyn A, Williams, Darlisha A, Morawski, Bozena M, Bangdiwala, Ananta S, Meintjes, Graeme, Muzoora, Conrad, Meya, David B, Boulware, David R
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2020
Konular:
Online Only Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755087/
https://ncbi.nlm.nih.gov/pubmed/31912875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciaa016
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