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Adjunctive sertraline in HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial

BACKGROUND: Identifying new antifungals for cryptococcal meningitis remains a priority given the inadequacy of current therapy. Sertraline has previously demonstrated in vitro and in vivo activity against Cryptococcus. We evaluated the efficacy of adjunctive sertraline for cryptococcal meningitis in...

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Bibliografische gegevens
Gepubliceerd in:Lancet Infect Dis
Hoofdauteurs: Rhein, Joshua, Huppler Hullsiek, Kathy, Tugume, Lillian, Nuwagira, Edwin, Mpoza, Edward, Evans, Emily E., Kiggundu, Reuben, Pastick, Katelyn A., Ssebambulidde, Kenneth, Akampurira, Andrew, Williams, Darlisha A., Bangdiwala, Ananta S., Abassi, Mahsa, Musubire, Abdu K., Nicol, Melanie R., Muzoora, Conrad, Meya, David B., Boulware, David R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041360/
https://ncbi.nlm.nih.gov/pubmed/31345462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(19)30127-6
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