Adjunctive sertraline in HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial

BACKGROUND: Identifying new antifungals for cryptococcal meningitis remains a priority given the inadequacy of current therapy. Sertraline has previously demonstrated in vitro and in vivo activity against Cryptococcus. We evaluated the efficacy of adjunctive sertraline for cryptococcal meningitis in...

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Detalhes bibliográficos
Publicado no:Lancet Infect Dis
Main Authors: Rhein, Joshua, Huppler Hullsiek, Kathy, Tugume, Lillian, Nuwagira, Edwin, Mpoza, Edward, Evans, Emily E., Kiggundu, Reuben, Pastick, Katelyn A., Ssebambulidde, Kenneth, Akampurira, Andrew, Williams, Darlisha A., Bangdiwala, Ananta S., Abassi, Mahsa, Musubire, Abdu K., Nicol, Melanie R., Muzoora, Conrad, Meya, David B., Boulware, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041360/
https://ncbi.nlm.nih.gov/pubmed/31345462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(19)30127-6
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