Adjunctive sertraline in HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial

BACKGROUND: Identifying new antifungals for cryptococcal meningitis remains a priority given the inadequacy of current therapy. Sertraline has previously demonstrated in vitro and in vivo activity against Cryptococcus. We evaluated the efficacy of adjunctive sertraline for cryptococcal meningitis in...

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Publicado en:Lancet Infect Dis
Autores principales: Rhein, Joshua, Huppler Hullsiek, Kathy, Tugume, Lillian, Nuwagira, Edwin, Mpoza, Edward, Evans, Emily E., Kiggundu, Reuben, Pastick, Katelyn A., Ssebambulidde, Kenneth, Akampurira, Andrew, Williams, Darlisha A., Bangdiwala, Ananta S., Abassi, Mahsa, Musubire, Abdu K., Nicol, Melanie R., Muzoora, Conrad, Meya, David B., Boulware, David R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041360/
https://ncbi.nlm.nih.gov/pubmed/31345462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(19)30127-6
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