Total synthesis of Escherichia coli with a recoded genome

Nature uses 64 codons to encode the synthesis of proteins from the genome, and chooses 1 sense codon—out of up to 6 synonyms—to encode each amino acid. Synonymous codon choice has diverse and important roles, and many synonymous substitutions are detrimental. Here we demonstrate that the number of c...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Fredens, Julius, Wang, Kaihang, de la Torre, Daniel, Funke, Louise F. H., Robertson, Wesley E., Christova, Yonka, Chia, Tiongsun, Schmied, Wolfgang H., Dunkelmann, Daniel, Beranek, Vaclav, Uttamapinant, Chayasith, Llamazares, Andres Gonzalez, Elliott, Thomas S., Chin, Jason W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039709/
https://ncbi.nlm.nih.gov/pubmed/31092918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1192-5
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