A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation

Epidermal growth factor receptor (EGFR) activation by growth factors (GFs) relies on dimerization and allosteric activation of its intrinsic kinase activity, resulting in trans-phosphorylation of tyrosines on its C-terminal tail. While structural and biochemical studies identified this EGF-induced a...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Baumdick, Martin, Gelléri, Márton, Uttamapinant, Chayasith, Beránek, Václav, Chin, Jason W., Bastiaens, Philippe I. H.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155120/
https://ncbi.nlm.nih.gov/pubmed/30242154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06299-7
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