A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation

Epidermal growth factor receptor (EGFR) activation by growth factors (GFs) relies on dimerization and allosteric activation of its intrinsic kinase activity, resulting in trans-phosphorylation of tyrosines on its C-terminal tail. While structural and biochemical studies identified this EGF-induced a...

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書目詳細資料
發表在:Nat Commun
Main Authors: Baumdick, Martin, Gelléri, Márton, Uttamapinant, Chayasith, Beránek, Václav, Chin, Jason W., Bastiaens, Philippe I. H.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155120/
https://ncbi.nlm.nih.gov/pubmed/30242154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06299-7
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